Trial of 209 Adults Finds 7-kg Weight Loss for Fasting and Calorie Restriction in 6 Months
Updated
Updated · Medscape · Jun 23
Trial of 209 Adults Finds 7-kg Weight Loss for Fasting and Calorie Restriction in 6 Months
1 articles · Updated · Medscape · Jun 23
Summary
An exploratory analysis of a 209-person obesity trial found intermittent fasting with time-restricted eating and daily calorie restriction produced similar 6-month weight loss—7.38 kg and 6.99 kg, versus 2.44 kg with standard care.
Calorie restriction changed eating behavior more strongly, driving bigger gains in dietary restraint and larger drops in disinhibition and hunger; reduced disinhibition explained 15% of its weight-loss effect versus standard care.
Intermittent fasting did not show the same detectable mediation pattern, leading researchers to conclude the two strategies may reach similar weight loss through distinct behavioral pathways.
No significant between-group differences emerged for depression, anxiety, sleep quality, or most quality-of-life measures, though the authors said both active interventions delivered clinically relevant weight loss.