Modeling Protein Evolution with Generative Models: from Extant Sequence Data to Evolutionary Dynamics
Updated
Updated · arxiv.org · Jun 28
Modeling Protein Evolution with Generative Models: from Extant Sequence Data to Evolutionary Dynamics
1 articles · Updated · arxiv.org · Jun 28
Summary
Researchers have reviewed advances in modeling protein evolution using generative models trained on large protein sequence datasets.
The study highlights how models like Direct Coupling Analysis can infer evolutionary constraints and simulate protein evolution across various timescales.
These approaches could improve protein engineering, predict viral mutations, and deepen understanding of evolutionary dynamics, though challenges remain in model calibration and incorporating experimental data.