2025 Study Flags U-Shaped B12-Cancer Risk as Experts Warn on High-Dose Supplements
Updated
Updated · Daijiworld.com · May 13
2025 Study Flags U-Shaped B12-Cancer Risk as Experts Warn on High-Dose Supplements
3 articles · Updated · Daijiworld.com · May 13
A 2025 Vietnam study found a U-shaped pattern in vitamin B12 intake and cancer risk, suggesting both low and unusually high levels may be linked to harm.
Researchers and clinicians said the evidence is associative, not causal, and high blood B12 in cancer patients often reflects liver dysfunction or tumor-driven protein changes rather than excess usable B12.
High-dose B-vitamin supplements have not shown strong proof of cutting overall cancer risk or mortality, while some observational studies loosely tied long-term B6 and B12 use to slightly higher lung-cancer risk in certain groups.
Experts said deficiency remains the more common problem—especially in vegans, older adults and people with absorption disorders—and advised balanced intake, with long-term high-dose supplementation only under medical supervision.
Why could high B12 levels be a silent warning of an undetected cancer?
Is your daily vitamin B12 supplement secretly increasing your cancer risk?