Colorado Boulder Study Ties Erythritol to Weaker Brain Vessel Function After 3 Hours
Updated
Updated · Okdiario · May 7
Colorado Boulder Study Ties Erythritol to Weaker Brain Vessel Function After 3 Hours
1 articles · Updated · Okdiario · May 7
Human brain blood-vessel cells exposed to erythritol for 3 hours showed impaired function in a University of Colorado Boulder lab study published in the Journal of Applied Physiology.
Those cells made less nitric oxide, more endothelin-1 and more reactive oxygen species, changes linked to tighter vessels, oxidative stress and less reliable blood-flow control.
t-PA release also fell sharply when researchers challenged the cells with a clot-forming compound, suggesting weaker natural clot breakdown that could raise stroke risk.
The findings offer a possible mechanism for a 2023 Nature Medicine study in which people with the highest erythritol levels had roughly double the cardiovascular-event risk of those in the lowest quartile over 3 years.
The study does not prove erythritol-containing foods cause strokes in people, and European regulators said in 2023 evidence still did not establish a cause-and-effect link.
Beyond heart attacks, could a popular sweetener be paving the way for vascular dementia?
Is your favorite sugar-free food secretly increasing your risk of a stroke?