University of Rochester scientists extend mice lifespan with naked mole rat gene
Updated
Updated · ScienceDaily · May 10
University of Rochester scientists extend mice lifespan with naked mole rat gene
12 articles · Updated · ScienceDaily · May 10
The modified mice showed about a 4.4% rise in median lifespan, stronger tumour resistance, healthier guts and lower age-related inflammation.
Researchers transferred the naked mole rat version of the hyaluronan synthase 2 gene, boosting high molecular weight hyaluronic acid linked to cancer protection and healthier ageing.
The Nature study is presented as proof that longevity mechanisms from long-lived mammals may be adapted in other species, with researchers now exploring pre-clinical routes that could eventually benefit humans.
Beyond hyaluronic acid, what other anti-aging secrets does the naked mole rat hold for humans?
Can we borrow an animal's longevity secret without inheriting its hidden biological risks?
Is the key to anti-aging found in naked mole rats or our own 'junk DNA'?
Transferring Naked Mole-Rat Longevity: 4.4% Lifespan Boost in Mice Signals New Era for Anti-Aging Science
Overview
Researchers have achieved a major breakthrough by transferring the naked mole-rat Has2 gene into mice, successfully moving a proven longevity mechanism from one mammal to another. This genetic change led to a 4.4 percent increase in the mice’s median lifespan and improved their healthspan, showing that unique adaptations from long-lived species can benefit other animals. The study proves that nature’s most resilient creatures hold valuable biological tools, which could be adapted to enhance health and longevity in humans. This work marks a new era in aging research, highlighting the potential of evolutionary solutions for broader health improvements.