He named Khaled Zaarour information minister, moved Hamza Mustafa to the foreign ministry, appointed Bassel Sweidan agriculture minister and replaced governors in Homs, Quneitra and Deir Ezzor.
The late-night decrees mark Syria's first reshuffle since Bashar al-Assad's ouster, about 18 months into the five-year transitional period set by the constitutional declaration.
No official reason was given, but the changes follow protests over worsening economic conditions, criticism of government performance and complaints about nepotism after Sharaa replaced his brother as presidential secretary-general.
While trying Assad's cronies, is Syria's new leader building a new government or just a new inner circle?
Can a former wanted militant unite a nation plagued by poverty, sectarian divides, and resurgent terror threats?