Toronto piled up 20 hits, with Brandon Valenzuela driving in four runs and Ernie Clement going 5-for-5 with three runs.
A seven-run fifth inning broke the game open before the Blue Jays added six more runs across the seventh and eighth, while five relievers combined to limit Los Angeles to one run.
Trey Yesavage threw four scoreless innings but needed 87 pitches, and Toronto will try to complete a sweep on Saturday behind Eric Lauer against Jose Soriano.
Despite a rash of injuries, the Blue Jays crushed the Angels. How is this depleted roster still capable of such dominant offensive outbursts?
The owner says fans don't prioritize winning. Does this 14-1 loss prove his controversial business model has failed the Angels?