At Lindsey Nelson Stadium, fourth-ranked Texas fell 5-1 on Friday, and junior second baseman Mendoza exited in the first inning after a diving play.
Coach Jim Schlossnagle said he was not optimistic Mendoza would return this weekend as Tennessee ace Tegan Kuhns struck out 15 over seven scoreless innings and Texas fanned 19 times.
Aiden Robbins provided Texas's only run with an eighth-inning solo homer, while Dylan Volantis allowed three early runs before the Longhorns try to rebound Saturday.
Is Kuhns' 113-pitch masterpiece a sign of a new coaching philosophy or a major risk for a future MLB star?
Can Tegan Kuhns fix his 'third-round command' in time to secure a top MLB draft spot?