At American Family Field, the 24-year-old threw all 10 first-inning pitches at least 102.4 mph and finished with 41 pitches over 100 mph in six scoreless innings.
Milwaukee scored four runs off Max Fried in the second, Shane Drohan earned a three-inning save, and manager Pat Murphy said outfielder Brandon Lockridge will likely miss substantial time after a wall collision.
The win snapped the Brewers' five-game skid against New York and marked Milwaukee's first home shutout of the Yankees since 1992, while Misiorowski posted consecutive scoreless starts after last week's hamstring cramp.
Is baseball's new velocity king a revolutionary talent or the next victim of the sport's ongoing injury epidemic?
How did the Brewers transform a 'rollercoaster' rookie into the hardest-throwing starting pitcher in baseball history in less than one year?