The index closed at 612.14 as Germany's DAX fell 1.32%, France's CAC 40 lost 1.09% and Britain's FTSE 100 dropped 0.43% in a second straight daily decline.
Rheinmetall led Stoxx 600 fallers, down 9.2%, followed by Genmab, LPP, Renk and Hensoldt, while BT Group topped gainers with a 6.6% rise ahead of Prysmian, Swatch, Nokia and Whitbread.
Sterling rose 0.58% against the dollar and the euro gained 0.45%, Brent crude climbed 1.67% to $101.73, while UK 10-year gilt and German bund yields edged lower.
Why is the pound strengthening amid an oil shock that threatens to push the UK into recession?
With trade threats and Mideast conflict roiling markets, is Europe on the brink of a 1970s-style stagflation crisis?
Are Europe's defense giants becoming obsolete in the new age of cheap drone warfare?