Shares closed at $44.46 on Thursday as the S&P 500 fell 0.38% and the Dow Jones Industrial Average dropped 0.63%.
The decline ended a two-day winning streak, leaving CSX 4.49% below its 52-week high of $46.55 reached on 23 April.
CSX lagged rail rivals Union Pacific and Norfolk Southern, which fell 1.25% and 1.22%, while trading volume rose to 13.4 million shares, above its 50-day average.
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