At Madison Square Garden, Jalen Brunson scored 26, including eight in the fourth quarter, while Karl-Anthony Towns finished with 20 points, 10 rebounds and seven assists.
Philadelphia, playing without Joel Embiid, got only seven second-half points from Tyrese Maxey, who shot 9-for-23 with six turnovers as the 76ers managed 12 fourth-quarter points.
The win ended Brunson's run of five straight playoff games with at least 35 points against Philadelphia, while OG Anunoby appeared to suffer a right hamstring injury late on.
Is Philadelphia's playoff fate sealed, or can Tyrese Maxey lead a historic comeback without a healthy Joel Embiid?
Did the Knicks' crucial Game 2 victory actually jeopardize their championship hopes with OG Anunoby's injury?
Has Karl-Anthony Towns finally become the reliable co-star the Knicks need for a deep playoff run?