The 54-year-old left about 90 minutes into Wednesday's four-hour programme, with Craig Melvin telling viewers on the plaza she would return the next day.
A source told Page Six Guthrie left for an appointment and that it was unrelated to the disappearance of her mother, Nancy Guthrie; NBC did not immediately comment.
Guthrie recently returned after a two-month hiatus linked to the January kidnapping of her 84-year-old mother in Tucson, as the FBI and Pima County sheriff dispute early coordination.
Did a feud between the FBI and local police jeopardize the search for Savannah Guthrie's mother?
With DNA evidence and a $1M reward, why can't authorities identify the man who abducted Nancy Guthrie?
Inside Savannah Guthrie’s Sudden Departure from “Today” and the High-Profile Abduction Case of Nancy Guthrie
Overview
On May 6, 2026, Savannah Guthrie unexpectedly left NBC's "Today" show broadcast, prompting her co-anchor Craig Melvin to briefly address the situation. Neither Guthrie nor NBC provided an explanation, which fueled immediate speculation linked to her mother's ongoing disappearance investigation. However, sources clarified that her early exit was due to a personal appointment unrelated to the case. Nancy Guthrie vanished from her Tucson home on January 31, 2026, leading to an active criminal investigation involving key digital evidence and a public reward exceeding $1.2 million. The case remains unresolved, placing a heavy emotional burden on Savannah as she balances her public role with private grief.