The Minnesota ace left Sunday's game in Minneapolis against Toronto after striking out Yohendrick Pinango and walking Kazuma Okamoto, with rookie Andrew Morris replacing him.
Ryan has gone 2-3 with a 3.76 ERA in seven starts and is central to the rotation with Pablo Lopez out for the season after February Tommy John surgery.
The 2025 All-Star has otherwise been durable, making 30 starts last year, though he also left his first spring outing with lower back tightness before returning.
With their pitching staff decimated, can the Twins' unproven prospects salvage a season on the brink of collapse?
Is baseball's 'Pitching Injury Crisis' an unavoidable flaw in the modern high-velocity game?