The four astronauts — Reid Wiseman, Victor Glover, Christina Koch and Canada's Jeremy Hansen — are due on the 11:35 p.m. April 30 broadcast from Rockefeller Center in New York.
Their appearance follows a White House visit and comes after the 10-day mission launched from Cape Canaveral on April 1 and ended with a splashdown off San Diego on April 10.
Artemis II was the first crewed flight near the Moon in more than 50 years, and the astronauts have since been debriefing, reuniting with family and readjusting to Earth.
How will the technical and emotional lessons from Artemis II shape the next steps toward a permanent human presence on the Moon?
What crucial discoveries or challenges from Artemis II could determine the success or failure of future missions like Artemis III?