GLP-1 weight-loss drugs lose effectiveness with inconsistent use, study finds

9 articles · Updated · Penn Medicine · Apr 28

University of Pennsylvania researchers reported in mice that stop-start semaglutide use left animals 20% heavier than continuously treated peers after four months.
The intermittent group regained weight during every off period and could not return to prior low weights after restarting, suggesting repeated interruptions blunt later weight-loss response.
With about one in eight US adults reporting GLP-1 use and more than half discontinuing within 24 months, researchers say human studies are needed and clinicians should help patients preserve muscle mass.

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