Experimental drug restores memory and learning in mice with advanced Alzheimer's

11 articles · Updated · ECOticias · Apr 29

Case Western Reserve University researchers said six months of daily injections restored brain NAD+ to normal levels, with treated mice performing like healthy animals on recognition and navigation tests.
The treatment also reduced neuroinflammation, oxidative stress and blood-brain barrier leakiness, while cognition improved even though amyloid-beta plaques and tau-related changes remained in the brain.
Published in Cell Reports Medicine, the study found human Alzheimer’s brain samples had about 30% lower NAD+, but researchers cautioned mouse results may not translate to people and safety testing is still needed.

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