San Antonio leads the series 3-1 and hosts Portland at Frost Bank Center at 9:30 p.m. ET, with the Spurs favored by 11.5 points.
A Spurs win secures their advancement, while Portland must win to extend the series; San Antonio is a -600 moneyline favorite, Portland +440 underdog.
Portland is expected to fight hard for coach Tiago Splitter, possibly in his last game, as historical trends show large home favorites up 3-1 rarely cover the spread.
Will Spurs' dominance defy history, or will the desperate Blazers cover the massive spread?
With his job on the line, can Coach Splitter's strategy outsmart a superior Spurs team?
Can increased minutes for Robert Williams III be Portland's secret weapon against San Antonio?
Can Victor Wembanyama's historic playoff debut single-handedly end Portland's season tonight?
How will Portland's offense survive the Spurs' elite defense without star Damian Lillard?