PRICKLE1 regulates junctional neural tube morphogenesis and cell ingression independently of planar cell polarity
Updated
Updated · Nature.com · Apr 28
PRICKLE1 regulates junctional neural tube morphogenesis and cell ingression independently of planar cell polarity
4 articles · Updated · Nature.com · Apr 28
University of Queensland researchers used high-resolution live imaging in transgenic quail embryos to show that PRICKLE1 drives both mediolateral convergence and EMT-driven ingression of neuroepithelial cells.
Disrupting PRICKLE1 impairs medial cell ingression and causes localized neural tube defects by a novel mechanism uncoupled from classical planar cell polarity signaling.
These findings redefine the molecular basis of junctional neurulation, providing insight into human neural tube defects and building on prior work linking PRICKLE1 mutations to local spinal dysraphisms in birth defects.
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