Lund University researchers uncover genetic regulation behind molecular differences in blood types
Updated
Updated · SciTechDaily · Apr 27
Lund University researchers uncover genetic regulation behind molecular differences in blood types
10 articles · Updated · SciTechDaily · Apr 27
The team identified nearly 200 transcription factor binding sites across 33 blood group genes, revealing why rare variants like the Helgeson blood group have reduced CR1 levels.
Their findings explain why individuals with the same blood type can have dramatically different antigen levels, impacting blood transfusion safety and disease resistance, especially in malaria-prone regions.
The researchers' computational approach has since identified similar regulatory mutations in other blood groups, paving the way for improved diagnostic tests and deeper understanding of gene regulation in transfusion medicine.
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