A study of over 2,000 US adults with prediabetes found those with AC or CC variations of the vitamin D receptor gene had a 19% reduced risk of developing diabetes when taking high-dose vitamin D.
The research, published in JAMA Network Open, suggests vitamin D supplementation may benefit only certain genetic subgroups, potentially paving the way for more personalized diabetes prevention strategies.
Researchers caution against self-prescribing high vitamin D doses, noting current guidelines and possible risks, and emphasize the need for further studies to identify which prediabetic patients would benefit most from supplementation.
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