Magnesium Depletion in Adults Linked to Lower Klotho Protein and Aging Signals

5 articles · Updated · Earth.com · Apr 27

Zhijie Zhuang's team at Central South University analyzed 11,387 U.S. adults aged 40–79 using NHANES data.
The study found that higher magnesium depletion scores consistently correlated with lower blood Klotho levels, even after adjusting for health differences, highlighting a visible marker of hidden mineral strain.
Klotho protein helps regulate mineral balance and protect cells from stress. Researchers caution that the association is not causal, and recommend dietary magnesium intake over supplements for most people.

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