Cao, Spitz, Yu et al. demonstrated this beam in standard multimode fiber, applying it to two-photon imaging of mouse enteric nervous systems and minute-resolved 3D scans of a human blood-brain barrier model.
The new beam, generated by on-axis Gaussian launch, outperformed conventional Bessel beams with reduced sidelobes and enhanced aberration resilience, enabling high-throughput, stable three-dimensional biosystem imaging.
This breakthrough advances light-shaping technologies and bioimaging, offering improved tools for studying biological transport pathways and potentially accelerating research in neurodegenerative disease diagnostics and drug delivery.
How does MIT's new imaging method stack up against competing tech claiming even faster speeds?
Beyond medicine, could this physics breakthrough revolutionize high-speed internet through common optical fibers?
Could this laser that tames chaos finally unlock treatments for brain diseases like Alzheimer's?
What are the risks of using 'ultra-high power' lasers on delicate, living biological tissue?
Is the 'simple' setup for this powerful pencil beam practical for the average research lab to implement?
With a market projected to hit $18 billion, who will commercialize this technology first?