Emergency services responded to a fire on Mason Street at about 20:30 BST on Friday night, where firefighters rescued two young children who were later pronounced dead at the scene.
Two other children and a woman escaped the house before emergency crews arrived and were assessed by ambulance staff but did not require hospital treatment.
West Midlands Police have launched an investigation into the incident, while medics and firefighters provided immediate care to the rescued children, who tragically could not be saved.
Firefighters risk everything for rescues. What hidden dangers in residential fires pose the greatest threat to them?
Could new fire safety regulations, effective this month, have prevented the tragic Wolverhampton house fire?
As police investigate, what is the critical difference between an accidental fire and a criminal act?
How does the national effort to fix unsafe cladding relate to the fire risks inside older homes?
Does this tragedy reveal a pattern of vulnerability in certain types of UK housing stock?
What are the unseen psychological costs for the first responders who face these tragedies head-on?