Stanford University regenerates cartilage in mice and human tissue by inhibiting protein 15-PGDH
Updated
Updated · ScienceAlert · Apr 24
Stanford University regenerates cartilage in mice and human tissue by inhibiting protein 15-PGDH
6 articles · Updated · ScienceAlert · Apr 24
Researchers found that blocking 15-PGDH in old mice thickened worn knee cartilage and protected young, injured mice from developing osteoarthritis.
The same inhibitor applied to human tissue samples from knee replacement surgeries showed cartilage regeneration and reduced inflammation, suggesting a promising new approach for osteoarthritis treatment.
This method bypasses the need for stem cells, instead reprogramming existing chondrocytes, and could eventually reduce reliance on joint replacements, offering hope for millions affected by arthritis and age-related cartilage loss.
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