Medical specialists say some patients who lose significant weight on GLP-1 drugs develop thinner heel and forefoot fat pads, leaving feet bonier and sometimes painful.
The change is not a formal diagnosis or an Ozempic-specific side effect; doctors say similar fat-pad loss can follow any rapid or substantial weight loss, including bariatric surgery.
Reduced cushioning can make walking feel like stepping on bone or stones, increase calluses and shoe-fit problems, and in some cases alter gait enough to affect ankles, knees, hips or the lower back.
Doctors still stress that weight loss often improves overall foot health by cutting load on joints, and they advise protein intake, strength training, supportive shoes and podiatry care for persistent pain.
Research on how often GLP-1 users develop these changes remains limited, with physicians urging closer monitoring—especially for people with diabetes, who face higher risks of ulcers and pressure injuries.