Nature Biomedical Engineering Highlights Study Rewiring CAR-T Resistance in Solid Tumors via ATP-Calcium Axis
Updated
Updated · Oncodaily · Jul 7
Nature Biomedical Engineering Highlights Study Rewiring CAR-T Resistance in Solid Tumors via ATP-Calcium Axis
3 articles · Updated · Oncodaily · Jul 7
Summary
Nature Biomedical Engineering published a News and Views spotlighting research on how to overcome CAR-T resistance in solid tumors by turning tumor mechanosensing into a targetable signal.
The commentary says soft matrix environments activate an ATP-calcium axis that pushes cancer cells into stem-like, immunotherapy-resistant states, helping explain why CAR-T has struggled in solid tumors.
The highlighted study proposes rewiring that same mechanosensing pathway into a synthetic “kill me” signal, making otherwise elusive resistant cells vulnerable to CAR-T attack.
Maria Kalli and Triantafyllos Stylianopoulos framed the work as a step toward “mechanically informed precision oncology,” while USC's Yingxiao Wang credited first author Yunjia Qu for leading the project.