Roslin Institute Unveiled Dolly in 1997 as First Mammal Cloned From 1 Adult Cell
Updated
Updated · The Hindu · Jul 5
Roslin Institute Unveiled Dolly in 1997 as First Mammal Cloned From 1 Adult Cell
3 articles · Updated · The Hindu · Jul 5
Summary
276 attempts produced Dolly, the first mammal cloned from an adult cell, after Roslin scientists transferred a nucleus from an adult Finn Dorset udder cell into an enucleated egg.
July 5, 1996 marked the breakthrough birth after a 148-day gestation, but the team kept it secret until Nature published the work on Feb. 22, 1997.
The result overturned the prevailing early-1990s view that differentiated adult cells could not be reset to produce a full animal, unlike earlier clones made from embryo cells.
Ian Wilmut credited Keith Campbell and a wider Roslin team, with Campbell identifying that donor nuclei had to come from quiescent, non-dividing adult cells.
Dolly later became a global symbol in scientific and ethical debates over cloning, lived to age 6, had 6 lambs, and was euthanized in 2003 after developing lung tumors.