Cincinnati turned a hyped Jacob Misiorowski-Chase Burns matchup into a lopsided win, jumping ahead on Sal Stewart's first-inning homer and Jose Trevino's three-run shot in the fourth.
Misiorowski struck out 10 and allowed only four hits in five innings, but the two homers put Milwaukee in a 5-0 hole that its offense never erased.
Chase Burns held the Brewers to two runs over six innings, with Garrett Mitchell's fifth-inning homer and Brice Turang's RBI double providing Milwaukee's only scoring.
TJ Friedl's seventh-inning homer and eighth-inning RBI single sealed Cincinnati's first win over Milwaukee after the Brewers had won the first six meetings this season.