Wageningen Launches 26-Week PRECODE Fiber Trial for Cognitive Decline After 2024 Twin Study
Updated
Updated · ScienceAlert · Jul 2
Wageningen Launches 26-Week PRECODE Fiber Trial for Cognitive Decline After 2024 Twin Study
2 articles · Updated · ScienceAlert · Jul 2
Summary
PRECODE is testing three dietary fibers—chicory inulin, resistant dextrin and seaweed polysaccharide—against a maltodextrin placebo in adults over 60 with suspected cognitive decline.
For 26 weeks, participants take the supplements twice daily and undergo regular brain scans and cognitive tests, making it the first human study to track both cognitive and microbial effects of this fiber mix.
The trial builds on a 2024 King's College London twin study of 36 pairs that found inulin or FOS improved memory scores within 12 weeks and increased beneficial Bifidobacterium.
Researchers hope the larger, longer study will show whether cheap over-the-counter prebiotics can deliver sustained brain benefits through the gut-brain axis; results are expected in 2027.
If our gut is a 'second brain,' could nurturing it with fiber be the secret to preventing dementia?
Scientists linked a specific gut bacteria to better memory. Could a simple supplement be the key to boosting it?
PRECODE Study Status July 2026: Can Prebiotics Modulate the Gut-Brain Axis to Prevent Cognitive Decline?
Overview
The PRECODE trial is a highly anticipated, ongoing study designed to explore whether specific prebiotics and probiotics can influence the gut microbiome and improve health, especially in older adults with early signs of cognitive decline. Using a rigorous randomized, placebo-controlled design, PRECODE aims to uncover how changes in the gut can affect brain function and potentially prevent dementia. The trial stands out for its focus on understanding the mechanisms behind gut-brain interactions and its transparent approach, sharing detailed study design and scientific rationale before results are available. Final results are expected soon and could shape future treatment and prevention strategies.