Cedars-Sinai Study Links 5 Cups of Coffee to 47% Lower Liver Cancer Risk
Updated
Updated · Cedars-Sinai · Jun 30
Cedars-Sinai Study Links 5 Cups of Coffee to 47% Lower Liver Cancer Risk
3 articles · Updated · Cedars-Sinai · Jun 30
Summary
354,957 UK Biobank participants followed for a median 13 years showed lower risks of cirrhosis, liver cancer and liver-related death as coffee intake rose.
Five or more cups a day was associated with a 32% lower cirrhosis risk, 47% lower liver cancer risk and 42% lower liver-related death risk versus no coffee.
MRI scans and blood protein analyses offered biological clues: heavier coffee drinkers had less liver fat, iron, fibrosis and inflammation, with protein patterns tied to healthier liver function.
Benefits appeared even at 1-2 cups daily and were strongest around 3-4 cups; similar patterns in caffeinated and decaffeinated coffee suggest compounds beyond caffeine may matter.
Cedars-Sinai said the observational study does not prove causation and should not replace standard prevention measures such as limiting alcohol, maintaining weight and controlling metabolic risk.