Lower-Inflammatory Diet Cuts Dementia Risk 29% in Adults With Alzheimer’s Biomarkers
Updated
Updated · 2 Minute Medicine · Jun 29
Lower-Inflammatory Diet Cuts Dementia Risk 29% in Adults With Alzheimer’s Biomarkers
3 articles · Updated · 2 Minute Medicine · Jun 29
Summary
A Swedish cohort of 1,865 dementia-free adults over 60 found 240 dementia cases over 8.4 years, with lower-inflammatory eating linked to less dementia among people with elevated Alzheimer’s-related biomarkers.
The strongest associations appeared in participants with higher p-tau217, neurofilament light chain and GFAP levels, where better reversed Empirical Dietary Inflammatory Index scores were tied to hazard ratios of 0.71, 0.79 and 0.73.
Other healthy diet measures showed a different pattern: Alternate Mediterranean Diet and Healthy Eating Index adherence was associated with lower dementia risk mainly in participants with lower biomarker levels, not higher ones.
The findings suggest diet may remain relevant even after Alzheimer’s pathology is detectable, supporting dietary prevention strategies for both the general older population and people already at elevated neurobiological risk.