Study Links 4.4 Years of PPI Use to 33% Higher Dementia Risk
Updated
Updated · FemaleFirst · May 28
Study Links 4.4 Years of PPI Use to 33% Higher Dementia Risk
6 articles · Updated · FemaleFirst · May 28
More than 4.4 years of proton pump inhibitor use was associated with a 33% higher dementia risk in adults 45 and older, according to a Neurology study.
The U.S. research followed over 5,700 people with an average age of 75 for about 5.5 years and found 585 dementia cases during that period.
Among 4,222 non-users, 415 developed dementia—about 19 cases per 1,000 person-years—after researchers adjusted for age, sex, race, hypertension and diabetes.
Researchers said the findings show an observed link, not proof that PPIs cause dementia, and reported no similar association with short-term use.
PPIs including omeprazole, lansoprazole and pantoprazole are widely used for acid reflux, ulcers and indigestion, making prolonged use a broad public-health concern.
Your heartburn pill is linked to dementia. What are the safer, long-term alternatives for managing severe acid reflux?
Does heartburn medication truly cause dementia, or is it just a marker for other underlying health risks?
Does Long-Term PPI Use Increase Dementia Risk? A 2023 Review of Evidence, Mechanisms, and Clinical Guidance
Overview
Recent research, including a 2023 study in Neurology, has raised concerns about a possible link between long-term use of proton pump inhibitors (PPIs) and dementia risk. However, current evidence still recommends that patients who benefit from PPIs continue their medication, as the benefits often outweigh the potential risks. Much of the research on this topic relies on observational studies, which are important for understanding drug safety in real-world settings and over long periods. While these studies provide valuable insights, more research is needed to fully understand how cumulative PPI use might contribute to dementia development.