Texas A&M Researchers Reverse Brain Aging With 2-Dose Nasal Spray
Updated
Updated · ScienceDaily · May 26
Texas A&M Researchers Reverse Brain Aging With 2-Dose Nasal Spray
5 articles · Updated · ScienceDaily · May 26
Two intranasal doses restored memory and cognitive performance for months in aged models, according to a Texas A&M study published in the Journal of extracellular vesicles.
The spray delivers extracellular vesicles loaded with microRNAs directly into brain tissue, where they dampened chronic inflammation pathways including NLRP3 and cGAS-STING.
Researchers said the treatment also revived mitochondrial function, reduced oxidative stress and improved recognition and object-memory test results in both sexes.
The team has filed a U.S. patent and says the approach could eventually be developed for dementia, Alzheimer's, stroke recovery and age-related brain fog, though human testing still requires further research.
The findings come as annual U.S. dementia cases are projected to rise from about 514,000 in 2020 to roughly 1 million by 2060.
If a simple spray can reverse brain aging, how will society redefine the meaning of 'old age'?
This anti-aging spray works in mice, but what's the biggest hurdle to reaching human trials?
Could suppressing the brain's natural defenses to fight aging invite other diseases?
Reversing Brain Aging with a Nasal Spray: Preclinical Success and the Road to Human Use
Overview
Recent research has revealed a groundbreaking discovery in the fight against brain aging: a novel nasal spray that shows great promise in preclinical stages. This innovative approach is being explored for its potential to slow and even reverse cognitive aging, offering new hope for maintaining brain health as we age. The development of this therapy marks a significant step forward in addressing age-related cognitive decline. Researchers also see a future where the nasal spray could help stroke survivors rebuild lost brain function and significantly impact the course of cognitive decline in humans.