NAD+, NMN and Resveratrol Show 0 Convincing Human Anti-Aging Benefits

5 articles · Updated · The Conversation · May 20

Human studies have not shown convincing evidence that NAD+, NMN or Resveratrol slow ageing, despite heavy marketing around cellular repair, energy production and longevity.
NMN and related precursors can raise NAD+ levels—mainly in blood markers—but trials have yet to show clear gains in strength, cognition, frailty, muscle function or biological age.
Resveratrol looks promising in lab and animal work, but poor oral bioavailability limits what reaches human tissues; cardiovascular and anti-inflammatory trial results remain mixed.
Topical NAD+ products have even weaker support, with no clear proof ordinary creams deliver enough through skin to produce meaningful anti-ageing effects.
Long-term safety, optimal dosing and who might benefit remain unresolved, while exercise, sleep, diet, not smoking and limiting alcohol still have much stronger evidence for healthy ageing.

With the FDA targeting supplements, could the booming anti-aging market face a major crackdown?

Why do we spend billions on unproven pills when social factors better predict a long, healthy life?