Bar-Ilan Researchers Reverse 80% of Liver Aging Markers in Old Mice With SIRT6

5 articles · Updated · Ynetnews · May 19

One month after SIRT6 activation at 24 months old, elderly mice regained youthful liver chromatin patterns, with about 80% of age-linked changes reversed.
The Nature Communications study found SIRT6 reshaped chromatin—the DNA packaging that controls gene activity—while reducing inflammation and improving metabolic pathways in the liver.
In mice engineered to overexpress SIRT6 from birth, 95% of age-related chromatin disruption was prevented, suggesting the protein can both protect tissue early and restore it later.
SIRT6 has already been tied to longevity: Cohen’s earlier work said mice with extra SIRT6 lived 30% longer and showed better metabolism, lower cancer risk and improved energy use.
The findings point to a possible late-life liver therapy, though no such treatment is approved for humans; Israeli startup SirTLab is preparing for clinical trials.

If scientists can reverse aging in a mouse's liver, what is the biggest hurdle to rejuvenating our own organs?

This breakthrough targets the liver, but is reversing aging organ-by-organ a realistic path to a longer, healthier life?

As multiple teams race to reverse aging, could activating one 'fountain of youth' gene shut down another vital process?