DraftKings released early odds for all 16 Week 1 games after the 2026 NFL schedule came out, with Seattle opening as a 3.5-point home favorite over New England in the Wednesday opener.
Los Angeles drew the biggest spread at Chargers -11.5 against Arizona, while Detroit -7 versus New Orleans and Jacksonville -7 versus Cleveland were the only other touchdown favorites.
The board also highlights several tight matchups, including Bills -1.5 at Texans, Packers -1.5 at Vikings and Chiefs -2.5 against the Broncos, with quarterback health questions hanging over Kansas City and Denver.
Two marquee spots stand out beyond the numbers: Rams-49ers will be played in Melbourne in the NFL's first Australia game, and Patriots-Seahawks is a Super Bowl LX rematch after Seattle's 29-13 win.
The odds offer an initial snapshot of how bookmakers rate teams months before kickoff, though injuries, roster moves and quarterback decisions could shift lines significantly before Week 1.
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